Parkia speciosa Seeds Ethanol Extract as Co-chemotherapeutic Agent for Doxorubicin Toward Tongue Cancer

BACKGROUND: Parkia speciosa seeds have been reported to an anticancer property due the presence of various antioxidant compounds. Since potential uses P. for tongue cancer has not clearly disclosed, we conducted a study investigate properties seed ethanol extract (PSSEE) as well its effect on cardiac cells.METHODS: Tongue rat model were treated with/without Doxorubicin and concentrations PSSEE. After treatment, heart samples collected processed further histological examinations. epithelium thickness damaged tissues was observed by HE staining, while cell proliferation assessed Ki-67 immunohistochemistry. Analyses performed under upright light microscope measure thickness, state proliferation, degree tissue damage.RESULTS: Addition 400 mg/kg body weight (BW) PSSEE 4.6 BW reduced average epithelial Ki-67+ cells number. Upon addition Doxorubicin, damage in concentration dependent manner. Among all groups, group with had lowest percentage damage.CONCLUSION: number damage, could be co-chemotherapeutic agent toward cancer.KEYWORDS: speciosa, cancer, Ki-67, cardiotoxicity, co-chemotherapy